IMSB News

The prize by the German Society of Mass Spectrometry (DGMS) honors outstanding method developments in and applications of mass spectrometry in the life sciences. 

The group was one of 19 labs across ETH Zurich to be certified in the LEAF pilot project.

Stephan's thesis pivots on the integrated analysis of endothelial cells from different vascular beds. 

The prize is awarded by the Swiss Academies of Arts and Sciences in recognition of  innovative and impactful practices in the field of Open Research Data (ORD).

We congratulate Tomek for successfully defending his thesis on "Simulation-based metabolic flux inference" which, by his own words, all boils down to clouds vs. points. Well done!

The winner is selected by the ETH Student association to honor a individual that stands out for promoting excellence in teaching. Congratulations!

Congratulations! PS: No, Nicola wasn't involved in the selection :-)

For people passionate about metabolomics, mass spectrometry, and computational challenges.

For students of D-BIOL/D-HEST/D-BSSE

For students in D-BIOL/D-HEST/D-BSSE

For students of D-BIOL/D-HEST/D-BSSE

For students of D-BSSE/D-MATL/D-CHAB/D-BIOL

We are proud to publicly announce SLAW.

We are seeking for ambitioned PostDocs in the area of mass spectronetry (metabolomics and lipidomics) and computational biology or chemistry

We are happy to announce that Dr. Krystina Kupkova will start working with us from March!

In December Sarah Cherkaoui defended her thesis!

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A shiny Agilent 6546 QTOF was just installed! This is part of a long-standing collaboration with Agilent.

The Zamboni lab has been tasked by the PHRT EC to provide metabolomics in support of the personalized health initiative in Switzerland. Together with the PHRT Center for Proteoform Analysis, it will provide a one-stop shop for clinical mass spectrometry in Switzerland.

The project is a collaboration with the group of Tanya Petrova (University Lausanne) and Pia Ostergaard (St. George’s Hospital and University of London, UK). We aim at advancing our understanding of fundamental biological mechanisms driving formation and function of lymphatic vasculature in normal and pathological conditions.

We are delighted to announce that the PSSS consortium was selected by the SPHN and PHRT panels for funding (>5 Mio CHF). The Swiss-wide consortium is headed by Prof. Adrian Egli (Uni Basel) and Prof Karsten Borgwardt (ETH Zürich). The Zamboni lab is responsible for the molecular profiling of >8000 plasma samples.

We are glad to announce that our SFA-PHRT technology transfer project proposal "Strategies and standards for high-throughput, long-term, non-targeted metabolome analysis of human biofluids" has been funded!

The joint proposal that combines synthetic Biology (Prof De Mey, Ghent University) and systems biology (Zamboni lab) has been just approved by the FWO/SNF. Looking forward to joining forces!

We are honored and proud to announce that George Rosenberger (Aebersold lab), Daniel Sévin (Sauer lab), and Andreas Kühne (Zamboni lab) won the prestigious ETH Silver Medal for Oustanding Doctoral Theses. Congratulations!  

How do gene (knock-outs) affect metabolite levels? We tested this systematically for > 3'800 genes in E. coli and found several suprises.

A metabolome and network centric analysis of 18 breast cancer cell lines reveals a fine-grained metabolic heterogeneity. The study will appear in a special issue of Metabolic Engineering devoted to cancer metabolism. We thank the team of our collaborator Prof. Almut Schulze (Würzburg).

About 15'000 high-throughput, non-targeted metabolomics analyses were acquired to study >1'200 functionally uncharacterized proteins. The study was just published by Daniel Sévin and co. in Nature Methods.

We are proud to announce that our joint study with prestigious colleagues of IRB Bellinzona, ETH Zurich, MPI Martinsried finally published in Cell: from omics to mechanism and anti-tumor effect in mice!

We congratulate Maria for publishing her novel method for targeted 13C flux ratio analysis.

We congratulate Prof. Christoph Kaleta (Jena), his team, and all collaborators for their achievement!

We are proud to announce that our paper on The yeast cyclin-dependent kinase routes carbon fluxes to fuel cell cycle progression was published today in Molecular Cell. The study was conducted jointly with Jenny Ewald and Jan Skotheim (Stanford).  

Our SNF Sinargia work with the Martinou Lab (U. Geneva) was published in PLoS Genetics. Congratulation to his team, Petra and Manuel!

The subject of his massive work was "Development and application of graph-based computational methods to elucidate the functional role of metabolism in human skin". Congratulations!

We congratulate Daniel for his work on "Nontargeted metabolomics appraoches for enzyme discovery and high-resolution metabolome profiling"

We congratulate with Prof. Trajkovski (U. Geneva) for demonstrating how "Gut Microbiota Orchestrates Energy Homeostasis during Cold" and Prof Ristow (ETH Zurich) to demonstrate the role of branched chain amino acids in regulating aging.

In a collaborative effort of the Sauer and Zamboni labs at IMSB and the Berry Lab at NIH, Michael and his co-workers integrated dynamic changes in the secretion and uptake of metabolites with genome-scale metabolic network reconstructions and identified active metabolic routes necessary for mycobacteria survival under hypoxic conditions.

The Zamboni and Sauer Lab developed a platform for real-time metabolome profiling by directly injecting living bacteria, yeast or higher cell suspensions into a high-resolution time-of-flight mass spectrometer. We congratulate Hannes and all the coauthors.

Amelia joined the lab as an Academic Guest from the Università La Sapienza of Rome to exploit non-targeted metabolomics in the context of doping.

The article was picked by the Editor in Science Signaling. A preview commentary by Dick and Ralser published in Molecular Cell.

Just published in Molecular Cell. We congratulate our collaborator Jean-Claude Martinou (U. Geneva) and his team for the invention. 

To timely celebrate one of the hottest and sunniest Summers, the Zamboni lab published a study elucidating a mechanism that allows skin cells to immediately fight oxidative damage before long-term countermeasures are available. We congratulate Andreas, Hila, and our collaborators at Beiersdorf AG

The study conducted by Prof Krek was published in Nature and demonstrates how alternative splicing mediates a metabolic switch that bypasses carbohydrate assimilation in cardiac cells. We congratulate our collaborators!

The vignette was contributed jointly with the colleagues Prof Gary Patti (Washington University) and Prof Alan Saghatelian (Salk Institute)

Este Peroza published the invention in Analyst.

The collaboration was led by Prof. Almut Schulze from the University Würzburg and published in the Journal of Pathology. Congratulations!

We congratulate our alumnus Este and our collaborator J. Ewald from the Skotheim lab at Stanford

We congratulate and thank Daniel and Andreas for assembling this criticial review.

Congratulations!

Tobias Fuhrer and Nicola Zamboni reviewed the current standing of HT metabolomics in the context of discovery.

Andreas Kühne won a Poster Prize at the D-BIOL Symposium in Davos. Congrats!

Alpha-Keto acids (e.g. glyoxylate, oxaloacetate, pyruvate, ...) are highly reactive and thus unstable compounds. We established a new method for in situ stabilization and quantification by mass spectrometry. The technique also allows determination of labeling patterns.

The Zamboni lab contributed to a study led by Prof. Ristow of ETH Zurich

and will work on mechanisms of acquired drug resistance

The Zamboni lab demonstrated and applied a method for selective and yet non-targeted profiling of Coenzyme A derivatives in cellular extracts

We congratulate Andreas Kühne for winning a Best Poster Award at the Conference on Systems Biology of Human Diseases in Heidelberg

Welcome!