Master/Semester Project: Complexity of mitochondrial transporters and metabolic rewiring III

Mitochondria express a family of small molecule transporters that remain poorly characterized in homeostatic and diverse disease settings. It remains unclear how overexpression of many transporters alters metabolism and what this means in the context of cancer or developmental biology. Interestingly, humans exhibit tissue-specific expression of mitochondrial transporters to define metabolic niches. This project for a 3 or 6 month master’s student dives into the metabolic complexity of mitochondria and mitochondrial transport. Specifically, the student will use state-of-the-art chemoproteomics to explore the consequences of over-expression (or loss) of one or more metabolite transporters in a human cell culture system. This project involves the mapping of mitochondria-specific post-translational modifications, integrating omics datasets, and human tissue culture.

For more information please contact Dr. Peter Doubleday at