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Non-targeted metabolomic investigation of Yeast nutrient sensor mechanisms of action

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Hafen Lab: Master thesis/semester project on CRISPR/Cas9-mediated SNP changes to elucidate cause of size variations

How genetic variation (e.g. SNP) leads to different traits/phenotypes in natural populations is a fundamental and challenging problem in both the life and medical sciences. This project will involve several objectives to tackle this problem by first establishing an efficient in vivo CRISPR/Cas9 method and then using this method to change phenotype-associated SNPs in inbred Drosophila lines derived from a natural population. Read more 


Aebersold lab: Master thesis/semester project in quantitative AP-MS of signalling complexes

TNF-alpha is a cytokine playing a central role in inflammation that induces the formation of a large signaling complex associated with its receptor. The project will primarily entail the application of quantitative mass spectrometry methods to obtain detailed information about this large assembly. The student will learn protein purification, experimental and computational aspects of AP-MS, and is expected to know basics of mass spectrometry and cell culture. Read more 


Zamboni lab: PhD Position available on cancer metabolism

Interested in understanding how cancer cells overcome metabolic inhibition? Read more 


Professor Ruedi Aebersold awarded Barry L. Karger Medal

Prof. Ruedi Aebersold has been awarded Barry L. Karger Medal for significant contribution to the development of new bioanalytical methods. Congratulations! Read more 


Three (!) IMSB students win ETH Prize for oustanding doctoral thesis

We are honored and proud to announce that George Rosenberger (Aebersold lab), Daniel Sévin (Sauer lab), and Andreas Kühne (Zamboni lab) won the prestigious ETH Silver Medal for Oustanding Doctoral Theses. Congratulations!   Read more 


Aebersold lab: student project focused on method development in chemical cross-linking/mass spectrometry

Most proteins execute the in the form of protein complexes. Chemical cross-linking coupled to mass spectrometry is a strategy to learn about the spatial organization of protein complexes. Our group is one of the world-wide leaders in this field. We are continuously optimizing our workflows and are looking for students to support us in this endeavor. The student will learn how to perform cross-linking experiments and perform the data analysis. For further information, contact Dr. Michael Ewing Read more 


Aebersold lab: Master thesis/semester project in interactomic studies of signaling complexes

The most widely utilized mass spec(MS)-based method to determine protein-protein interaction is based on affinity purification (AP-MS). Recently, a suite of methods have been developed to determine the proximal proteome of a target protein by biotin labeling, providing information complementary to AP-MS. In this project, the student will apply a combination of AP-MS and proximity labeling to exhaustively define the full and dynamic interactome of key players in innate immunity.  Read more 


HFSP scholarship won by Duncan Holbrook-Smith

Duncan Holbrook-Smith won a prestigious HFSP scholarship for his postdoc project at the Sauer lab, on exploiting non-targeted metabolomics for parallelized discovery of chemical probes for receptor-like proteins, and using those chemical probes to better understand the specific roles of receptor-like proteins in that system. Now he has the problem of deciding which fellowship to accept……… Read more 


Aebersold lab: Semester project in identification of plant membrane protein-protein interaction

All plant cells are encapsulated by a cellulose-rich cell wall, which performs a range of functions in plant growth and development. Despite extensive research, little is known about the biosynthesis of the cellulose. This project aims to explore methods of detection of the cellulose synthase complex within the Golgi apparatus of Arabidopsis. The student will work on detergent selection for complex solubilization, after which he/she will perform AP-MS and subsequent data analysis. Read more 


Welcome Jonathan Venetz

Jonathan joined the Christen lab for his PhD. Read more 


Eirini's paper accepted in Nature Communications

Sensitive detection of rare disease-associated cell subsets via representation learning. Using CellCnn, we identify paracrine signaling-, AIDS onset- and rare CMV infection-associated cell subsets in peripheral blood, and extremely rare leukemic blast populations in minimal residual disease-like situations with frequencies as low as 0.01%. Read more 


Semester students join the Christen Lab

Celine Margot, Yves Buchner and Philipp Schächle join our team and will carry out their semester research projects in systems and synthetic biology. Read more 


Welcome Kathrin Frey

After completing already her semester project in the Wollscheid lab, Kathrin now started her Master thesis investigating the uptake and the involved signalling pathway of HDL particles. Read more 


Michael Zimmermann and Paul Murima won the Swiss TB 2017 Award!

Michael Zimmermann and Paul Murima won the Swiss TB 2017 Award for their Nature Communications paper "A rheostat mechanism governs the bifurcation of carbon flux in mycobacteria." CONGRATULATIONS! Read more 


Claassen Group: Postdoctoral researcher position: single cell transcriptomics time series models for personalized medicine.

The Claassen group at the Institute for Molecular Systems Biology, ETH Zurich is offering a position for a postdoctoral researcher in computational single cell biology Read more 


Genome-wide landscape of gene-metabolite interactions charted for bacterium

How do gene (knock-outs) affect metabolite levels? We tested this systematically for > 3'800 genes in E. coli and found several suprises. Read more 


Semester project (Sauer group): Discovery of novel kinases in E. coli that regulate enzyme activity

Research project available on the discovery of novel kinases in E. coli that are crucial for enzyme activity regulation in metabolism. Read more 


Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics

A metabolome and network centric analysis of 18 breast cancer cell lines reveals a fine-grained metabolic heterogeneity. The study will appear in a special issue of Metabolic Engineering devoted to cancer metabolism. We thank the team of our collaborator Prof. Almut Schulze (Würzburg). Read more 


Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli

About 15'000 high-throughput, non-targeted metabolomics analyses were acquired to study >1'200 functionally uncharacterized proteins. The study was just published by Daniel Sévin and co. in Nature Methods. Read more 

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