Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data
The Sauer Lab developed an experimental-computational approach to identify regulatory needles in metabolic haystacks. By using steady-state 13C flux, metabolites and transcript data, the approach revealed the sparse and transition-dependent regulators that drive transitions between carbon sources in Escherichia coli. Thus, pseudo-transition analysis is a novel approach to efficiently explore the vast regulatory landscape of dynamic adaptations using relatively few stationary observations.
Real-time metabolome profiling of the metabolic switch between starvation and growth
The Zamboni and Sauer Lab developed a platform for real-time metabolome profiling by directly injecting living bacteria, yeast or higher cell suspensions into a high-resolution time-of-flight mass spectrometer. We congratulate Hannes and all the coauthors.
The acute response of skin cells to oxidative stress and sun irradiation
To timely celebrate one of the hottest and sunniest Summers, the Zamboni lab published a study elucidating a mechanism that allows skin cells to immediately fight oxidative damage before long-term countermeasures are available. We congratulate Andreas, Hila, and our collaborators at Beiersdorf AG