Aebersold Lab, Proteomics, Cholesterol regulation

Cholesterol regulation is a crucial cellular process underlying the complex trait of elevated blood lipid levels and cardiovascular disease. It is a well-studied biological process with immense clinical importance but a comprehensive and mechanistic understanding of all the proteins implicated in the regulation mechanisms is lacking. Employing state-of-the-art mass-spectrometry techniques developed in our lab, we want to understand cellular cholesterol regulation using a systems biology approach.

We are looking for a highly motivated MSc student with skills and interest both in cell biology, biochemistry and computational biology. The project will include preparing samples using human cell lines by applying pharmacological or genetic perturbations of cellular cholesterol regulation, sample preparation for mass-spectrometry, and analyzing/quantifying the proteins in the sample using computational analysis pipelines.

Contact: Dr. Peter Blattmann