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News & Events
IMSB News
2023
2022
01
Warm welcome to the Beltrao Group
Congratulations to Patrick Stalder!
2021
01
Not a bike day! Bless home office.
Congratulations to Philipp Warmer for successful defence of his PhD thesis!
02
The Sauer group welcomes Julian Trouillon to his new post-doc position
Sarah Cherkaoui defended her PhD at the Zamboni lab, congratulations!
04
Zamboni lab guests Dr. Krystina Kupcova
Our collaborative paper on modeling signaling networks is published.
05
Pedro Beltrao joins IMSB
06
Paper on genome design principles published
We are hiring!
Welcome to Viviane Reber
2020
01
02
04
Tactile sensing controls cell-cycle initiation in bacteria
06
Paola Picotti receives this year’s Rössler Prize
How bacteria fertilise soya
07
A universal trade-off between growth and lag in fluctuating environments
Paola is elected to the German academy of Sciences.
12
IMSB Xmas in times of Corona
Our paper on proteome-wide structure-function is published.
2019
01
Welcome to Aleš!
03
04
(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch
De novo Classification of Mouse B Cell Types using Surfaceome Proteotype Maps
First Computer-Generated Genome published in PNAS
05
ETHics event at Audimax
06
Welcome to Franziska!
Welcome to Jan-Philipp!
Welcome to Natalie!
Paola wins EMBO gold medal!
Our paper on Parkinson’s disease out in Science Translational Medicine!
Leitner group news Q1/Q2 2019
07
Master/semester project - Prediction and characterization of unknown membrane protein function
Regulatory mechanisms coordinating amino acid and glucose catabolism in E. coli
ETH spin-off Gigabases Switzerland AG founded
Beat Christen speaks at the World Economics Forum on Digital Genome Design Algorithms
08
Research on Computer-generated Genomes featured in NZZamS
10
Our paper on alpha-synuclein toxicity out in Cell Systems!
Patent on Parallel Functionality Testing Synthetic Genome.
11
PHRT Hub for Clinical Mass Spectrometry
12
New NCCR with IMSB participation
Farewell lecture by Ruedi Aebersold
Master Graduation Ceremony
Classen group moves to Tübingen
New Mass Spectrometer for the Zamboni Lab
30 Mass Spectrometers!
A life devoted to protein research
Paola Picotti receives ERC Consolidator Grant with EUR 2 Mio
Paper on field-portable bio-sensor device published.
2018
01
Paper using LiP for identification of protein-metabolite interactions now out in Cell!
02
Our Cell Paper on Protein-Metabolite Interactions Recommended in F1000, twice
Sauer-Picotti collaboration results in publication in Sci Transl Med
04
New students at Aebersold group!
Absolute stoichiometry determination of dynamic protein complexes
06
PanCancer blood proteome analysis published in Cell Reports!
Prizes for Paola and Ilaria at EuPA 2018
Leitner group news Q1/Q2 2018
07
Welcome to Marie
Welcome to Christian
TnSeq study in Brucella published
10
Video lectures from DIA/SWATH course are online!
DIA/SWATH tutorial published in MSB
Welcome two new PhD student to the Wollscheid group!
Several new publications by the Wollscheid lab
Ilaria wins Early Career Researcher competition!
Review about Surfaceome Nanoscale Organization now online!
In silico human surfaceome published!
Monika awarded the ETH Medal for Outstanding Master Theses
11
We moved our lab!
Welcome back Alex
In silico surfaceome paper was recommended by F1000
Research paper published on chemical diguanylate cyclases modulators
The protein with the starting gun
We moved our lab
Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli
12
Leitner group news Q3/Q4 2018
2017
01
Genome-wide landscape of gene-metabolite interactions charted for bacterium
Michael Zimmermann and Paul Murima won the Swiss TB 2017 Award!
Welcome Kathrin Frey
02
Eirini's paper accepted in Nature Communications
Our study on the determinants of proteome thermostability was just published in Science!
Our Science paper on proteome thermostability highlighted in ETH News
Article in Neue Zürcher Zeitung about our paper in Science
03
HFSP scholarship won by Duncan Holbrook-Smith
Highlight in BioTechniques
Faculty of 1000 recommendation for our Science paper
05
Three (!) IMSB students win ETH Prize for oustanding doctoral thesis
Professor Ruedi Aebersold awarded Barry L. Karger Medal
Hafen Lab: Master thesis/semester project on CRISPR/Cas9-mediated SNP changes to elucidate cause of size variations
Our Science paper discussed in Quanta Magazine
06
Our computational platform to accelerate genome synthesis is published in PLoS One.
08
Charlottes's review on host-pathogen protein interactions is published in COM
Hafen lab: Master’s thesis and/or semester project on the role of cryptic genetic variation on circadian behaviors
Study comparing performance of SWATH-MS across labs is published in Nature Communications
Paper outlining best practice in error rate control in DIA/SWATH studies published
Collaborative effort published in Nature Cell Biology
10
The Picotti lab joins IMSB
Amir's review describing proteomics approaches in Mycobacterium tuberculosis is published in COM
TnSeq analysis of Bacterial Methyotrophy published in Current Biology
Review on Quantitative proteomics of model organisms published in COSB
Hafen Lab: Semester project and/or Master thesis on the genetics of inter-individual variations in human sensory perception
Nature Protocols paper describing Limited Proteolysis coupled to MS now out
Welcome to Patrick and Monika
11
Master thesis in Wollscheid Lab
The Zamboni lab receives a grant for the standardization of non-targeted metabolomics in personalized health
Project on metabolic engineering of the hexosamine pathway gets funded!
"Personalized Swiss Sepsis Study" selected as a driver project by the SPHN and PHRT!
Nationaler Zukunftstag @ D-BIOL
Personalized health: several IMSB proposals funded
Joint proposal on lympathic endothelial cells approved by SNF Sinergia!
12
Our SPHN/PHRT Driver project PRECISE got approved!
Claassen lab: PostDoctoral position in computational single cell biology of auto-immune diseases
Friedrich-Miescher-Award for Paola
Leitner group news Q3/Q4 2017
2016
01
Hafen Group: Functional Validation of Genes Associated with Starvation Resistance
SCNAT Rigi workshop on Systems and Synthetic Biology of Microbes
Aebersold Lab, Proteomics, Method development in the field of phosphoproteomics
Aebersold Lab, Proteomics, Method development in chemical cross-linking
Aebersold lab, Proteomics, Computational mass spectrometry and Immunology
Aebersold Lab, Student project on proteomic analysis of epigenetic states during aging and cancer
EMBO fellowship for Valentina
Yuehan and Paola wrote a practical guide to measuring proteins by SRM
02
Paper on quantitative selection analysis featured in JMB
Wollscheid Lab, Master Thesis in Receptor Nanoscale Organisation & Cellular Signaling
Just out: two papers we contributed to.
03
Christen Lab: Master Thesis Project in Experimental Systems Biology
Claassen Lab Semester Project: Deep Learning for dynamic system motif detection in health and disease
Donation of Lotte and Adolf Hotz-Sprenger Foundation for Prostate Cancer Digital Biobanking
F1000 award at the Life Sciences PostDoc day 2015 for Christian Feller
Elucidation of Genetic Interactions in the Yeast GATA-Factor Network Using Bayesian Model Selection
Stocker lab, Master Thesis Project on impact of amino acids on tumor growth
The maternal microbiota drives early postnatal innate immune development
Paola wins Robert J. Cotter New Investigator Award 2016
Nature Biotechnology asked Paola's opinion, this is what she said
04
Daniel Sévin defended his PhD thesis
One metabolite to bind them – using ligand-detected NMR to fish out protein-metabolite interactions
Master thesis in Wollscheid Lab
Andreas Kühne defended his PhD thesis
ChristenLab, Block-course in Synthetic Genomics
Charlotte Nicod joins the group as PhD student
Paola winner of the 2016 SGMS award!
Martin awarded silver medal for "Outstanding Doctoral Theses"
05
Nino Nikolovski is starting as a postdoc at Aebersold lab with Marie Curie Individual Fellowship
Christian Feller obtained grant for melanoma epigenetic profiling
Aebersold group: Student project to monitor epigenetic states in melanoma cells using novel proteomic tools
Ketogenic diet rescues mouse embryos missing the mitochondrial pyruvate carrier
A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism published
Cell cycle coordinates carbohydrate metabolism in yeast
Uwe Sauer newly elected EMBO Member
06
Annie Champagne Queloz defended her PhD Thesis
Lund University awards honorary doctorate to Prof. Ruedi Aebersold
Welcome Lili!
08
Zamboni group, Metabolomics & network analysis
09
SUMOFLUX paper published!
Welcome to Valentina and Thomas
10
Welcome Fabian Wendt
Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Mcs and semester students join the ChristenLab
11
Justins' paper came out in Cell Systems
Anna's paper accepted in PLOS Computational Biology.
Future Day at ETH
Welcome Mariëlle Van Kooten
12
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals
Sauer group: Metabolomics and Flux Balance Analysis in Saccharomyces cerevisiae (Semester/Master Project)
Sauer group: Interplay of posttranslational modification sites in enzyme activity regulation (Master project)
Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in
Escherichia coli
Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics
Visit of Emily LeProust at ETH
2015
01
Sauer Lab, Metabolomics, Functional genomics
Welcome to Natalia and Marco
02
Population level variability of plasma protein abundance
Proteomics review online
03
Sauer Group, Metabolomics, Modeling, Bistability
Sauer Group, Metabolomics, Screening, Physiology
Research Assistant/PhD student
Research Assistant/PhD student
PhD position in structural proteomics of kinase complexes
Hafen Group, Functional Validation of Genes Associated with Starvation Resistance
Hafen Group, Determination of Sexual Dimorphism in Larval Starvation Resistance
SNF proposal approved!
Martin Soste got his PhD!
04
CSPA published in PlosONE
Claassen Group: Causality from single-cell data
Paper published on FRET sensor for Trehalose-6-P
Andre succesfully defended his PhD!
05
Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival.
Causal metabolic signals and functionality of protein phosphorylation in TOR signaling identified
An novel method for rapid and randomized prototyping of FRET sensors for small molecules
We congratulate Manuel Hörl for succesfully defending his PhD thesis!
Review on Metabolomcs and Flux Analysis published in Molecular Cell
Master Thesis Project in Proteomics, Computational mass spectrometry and Immunology
Master Student Project in Proteomics, Epigenetics in Aging and Cancer
06
Sauer Group, Allosteric Regulation, Metabolic Network, Kinetic Modeling
Christian Feller was selected for an EMBO Long-Term Fellowship
Hypoxia-induced consumption of fructose provokes heart disease
Peter Blattmann received extension of his SystemsX.ch Transition Postdoc Fellowship
07
Sauer Group, Metabolomics, Antibiotics, More of action
The acute response of skin cells to oxidative stress and sun irradiation
Sauer group: Develop a technique for robust and automatized cell counting
Our bioinformatic genome refactoring approach is published in ACS Synthetic Biology
TnSeq paper on uranium detoxification published
08
Sauer Group, Oxidative Stress, Metabolomics, Kinetic Modelling
A biosensor for the activity of mitochondrial pyruvate transport
Welcome Maik Müller
Sauer Lab, Predicting antimicrobial interactions
An open-source computational and data resource to analyze digital maps of immunopeptidomes
Sauer Lab, Relating stochastic fluctuations of metabolic gene regulation to antibiotic tolerance
Our paper on acute PPP activation featured in the press
We welcome Amelia Palermo!
Yvonne Bösch completed her Master
09
Aebersold lab, student (master) project in phosphopeptide enrichment.
Real-time metabolome profiling of the metabolic switch between starvation and growth
Posttranslational regulation of microbial metabolism
Cyclic operation of the pentose phosphate, Entner-Doudoroff and glycolytic pathways in Pseudomonas putida
The outer mucus layer hosts a distinct intestinal microbial niche
Sauer Group, Metabolism, Systems Biology, Modelling, Bistability
Aebersold lab: Master thesis/semester project in Structural Proteomics
Targeted Proteomics course registration is open!
10
Dynamic exometabolome analysis reveals active metabolic pathways in non-replicating mycobacteria
Wollscheid Lab: Master Thesis in Receptor Nanoscale Organisation & Cellular Signaling
Pseudo-transition Analysis Identifies the Key Regulators of Dynamic Metabolic Adaptations from Steady-State Data
We welcome Martin Spillmann and Donat Appert
US patent issued!
Christen Lab: New openings for Master students
Paola named EMBO Young Investigator
Welcome to Valentina Cappelletti
11
Luca Del Medico starts his PhD
Ulrich Genick awarded with “Golden Owl” of the VSETH
12
Two new papers published by our collaborators
2014
2013
2012
2011
2010
The Institute
History
How to Find Us
People
Principal Investigators
Staff
Research
Beltrao Group
Research
People
Prof. Dr. Pedro Beltrao
Dr. Jürgen Jänes
Dr. Miguel Correa Marrero
Dr. Emmanuel Matabaro
Dr. Diederik Laman Trip
Dr. Ryan Separovich
Ellen Aarts
Andrina Caduff
Gauss Sophia
Dr. Mario Leutert
Dennis Gankin
Julian van Gerwen
Elena Krismer
Dr. Stefano Pascarelli
Gudmundur Magnusson
Publications
Gstaiger Group
Research
People
Dr. Matthias Gstaiger
Alumni
Viviane Reber
Publications
Leitner Group
Research
People
Dr. Alexander Leitner
Christopher Sarnowski
Maria Bikaki
Benjamin Steinmetz
Publications
NCCR Structural MS Platform
Picotti Group
News
Research
Molecular bases of protein aggregation diseases
Allostery and protein-metabolite interactions
Determinants of proteome thermostability
Structural systems biology
People
Paola Picotti
Ludovic Gillet
Natalie de Souza
Lili Malinovska
Valentina Cappelletti
Tetiana Serdiuk
Franziska Elsässer
Jan-Philipp Quast
Dina Schuster
Cathy Marulli
Alumni
Mennat Allah Ahmed
Francesco Di Girolamo
Abdullah Kahraman
Andre Melnik
Natalia Prymaczok
Simone Schopper
Juan Gerez
Pascal Leuenberger
Yuehan Feng
Martin Soste
Thomas Hauser
Ilaria Piazza
Matthias Weith
Marco Tognetti
Fabian Sesterhenn
Marie-Therese Mackmull
Walther Hänseler
Christian Dörig
Aleš Holfeld
Monika Pepelnjak
Norbert Volkmar
Patrick Stalder
Maximilian Dünnebacke
Anna Pagotto
Thorben Schramm
Group Pictures
Publications List
Grants, fellowships and awards
Sauer Group
Research
Regulatory protein-metabolite interactions
Control of metabolic function through protein phosphorylation
Metabolic interactions: gut microbiome and host-pathogen interactions
Metabolic interactions: marine microbial communities
Escherichia coli
metabolism
Metabolic flux analysis
Metabolomics
People
Prof. Dr. Uwe Sauer
Dr. Emmanuel Matabaro
Dr. Sammy Pontrelli
Dr. Julian Trouillon
Dr. Andreas Sichert
Dr. Evgeniya Warmer
Dr. Dorothée Berthold
Christoph Gruber
Michelle Scharte
Vilhelmiina Haavisto
Jonas Runde
Alumni
Publications
Student Projects
Snijder Group
Research
People
Prof. Dr. Berend Snijder
Julien Mena
Yannik Severin, MSc
Tim Heinemann
Sohyon Lee
Daniel Greenwood
Rebekka Wegmann
Klara Kropivsek
Mattheus "Thijs" Wildschut
Ben Hale
Yasmin Festl
Ramon Pfändler
Lorenz Bankel
Lucie Kralickova
Ben Hale
Publications
Open positions
Zamboni Group
Research
13C Metabolic Flux Analysis
High throughput metabolomics
Quantitative metabolomics
People
Prof. Dr. Nicola Zamboni
Dr. Michele Stravs
Dr. Peter Doubleday
Dr. Lorenzo Talamanca
Tomek Diederen
Dr. Stephan Durot
Dr. Adriano Rutz
Dr. Mario Correia
Dr. Vincen Wu
Dr. Anna Weiser
Dr. Kate Wolfer
Publications
Resources
FiatFlux
anNET
External collaborations
Joint Projects
PHRT Center for Metabolomics and Lipidomics
Analytical services
Metabolomics
Lipidomics
Infrastructure
Fees
Former Faculty Members
Aebersold Group
Education
Courses
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Open Positions
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