Prof. Dr. Paola Picotti

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Prof. Dr. Paola Picotti
Deputy head of Institute for Molecular Systems Biology
  • HPM H 46
  • +41 44 633 25 58
  • +41 44 633 12 98
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Inst. f. Molekulare Systembiologie
Otto-Stern-Weg 3
8093 Zürich
Switzerland

Curriculum vitae

Professional and academic experience
2017-       Associate (Tenured) Professor for Molecular Systems Biology, Institute of Molecular Systems Biology, ETH Zurich
2011-17    Assistant Professor for Protein Network Biology, Institute of Biochemistry, ETH Zurich
2007-10    Post-doctoral fellow, Inst. of Molecular Systems Biology, ETH Zurich Supervisor: Prof. Ruedi Aebersold

Education
2006         PhD in Biotechnology, University of Padua, Italy. Supervisor: Prof. Angelo Fontana
2001         Master degree summa cum laude in Pharmaceutical Chemistry and Technologies, University of Padua, Italy

Honours and Awards
2021         HUPO Discovery in proteomics award
2021         Winner of the Life Sciences Falling Walls competition        
2021         Guest professorship at the University of Cologne
2020         Rössler Prize, ETH Zürich    
2020         Election to the German National Academy of Sciences (Leopoldina)
2019         EMBO Gold Medal
2019         ERC Consolidator Grant
2018         Juan Pablo Albar “Protein Pioneer” Award, European Proteome Organization
2018         Friedrich-Miescher Award

2016         Robert J. Cotter Award, American Human Proteome Organization
2016         SGMS Award for independent research in the field of MS
2016         EMBO Young Investigator Award
2014         ERC Starting Grant
2014         “Top 40 under 40” Power List, The Analytical Scientist
2012         ETH Latsis Prize
2011         Swiss National Foundation Research Professorship
2009         “Tomorrow’s PI”, Genome Technology
2007         Marie Curie Intraeuropean fellowship

Selected Publications

V. Cappelletti, T. Hauser, I. Piazza, M. Pepelnjak, L. Malinovska, T. Fuhrer, Y. Li, C. Dörig, P. Boersema, L. Gillet, J. Grossbach, A. Dugourd, J. Saez-Rodriguez, A. Beyer, N. Zamboni, A. Caflisch, N. de Souza, P. Picotti. external pageDynamic 3D proteomes reveal protein functional alterations at high resolution in situ. (2021) Cell, 184 (2), 545-559. e22.

I. Piazza, N. Beaton, R. Bruderer, T. Knobloch, C. Barbisan, L. Chandat, A. Sudau, I. Siepe, O. Rinner, N. de Souza, P. Picotti, L. Reiter. external pageA machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes. (2020) Nat Commun., 11 (1), 1-13.

I. Piazza, K. Kochanowski, V. Cappelletti, T. Fuhrer, E. Noor, U. Sauer, P. Picotti. external pageA Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication. (2018) Cell, Jan 3. pii: S0092-8674(17)31448-4. 

S. Schopper, A. Kahraman, P. Leuenberger, Y. Feng, I. Piazza, O. Müller, P.J. Boersema, P. Picotti. external pageMeasuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry. (2017) Nat. Protoc., Nov;12(11):2391-2410.

P. Leuenberger, S. Ganscha, A. Kahraman, V. Cappelletti, P.J. Boersema, C. von Mering, M. Claassen, P. Picotti. external pageCell-wide analysis of protein thermal unfolding reveals determinants of thermostability. (2017) Science, 355 (6327).

M. Soste, R. Hrabakova, S. Wanka, A. Melnik, P. Boersema, A. Maiolica, T. Wernas, M. Tognetti, C. von Mering, P. Picotti. external pageA sentinel protein assay for simultaneously quantifying cellular processes. (2014) Nat Methods,11(10):1045-8.

Y. Feng, G. De Franceschi, A. Kahraman, M. Soste, A. Melnik, P.J. Boersema, P.P. de Laureto, Y. Nikolaev, A.P. Oliveira, P. Picotti. external pageGlobal analysis of protein structural changes in complex proteomes. (2014) Nat. Biotechnol., 32(10):1036-44.

P. Picotti, M. Clément-Ziza, H. Lam, D.S. Campbell, A. Schmidt, E.W. Deutsch, H. Röst, Z. Sun, O. Rinner, L. Reiter, Q. Shen, J.J. Michaelson, A. Frei, S. Alberti, U. Kusebauch, B. Wollscheid, R.L. Moritz, A. Beyer, R. Aebersold. external pageA complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis. (2013) Nature, 494(7436):266-70.

P. Picotti, B. Bodenmiller, L.N. Müller, B. Domon, R. Aebersold. external pageFull dynamic range proteome analysis of S. cerevisiae by targeted proteomics. (2009) Cell, 138(4):795-806.

P. Picotti, O. Rinner, R. Stallmach, F. Dautel, H. Wenschuh, T. Farrah, B. Domon, R. Aebersold. external pageHigh-throughput generation of selected reaction-monitoring assays for proteins and proteomes. (2010) Nat. Methods, 7(1):43-6.

P. Picotti, H. Lam, D. Campbell, E.W. Deutsch, H. Mirzaei, J. Ranish, B. Domon, R. Aebersold. external pageA database of mass spectrometric assays for the yeast proteome. (2008) Nat. Methods. 5(11):913-4.

M.A. Krzyzaniak, M.T. Zumstein, J.A. Gerez, P. Picotti, A. Helenius. external pageHost cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein. (2013) PLoS Pathog., 9(4):e1003309.

F. Di Girolamo, P.G. Righetti, M. Soste, Y. Feng, P. Picotti. external pageReproducibility of combinatorial peptide ligand libraries for proteome capture evaluated by selected reaction monitoring. (2013) J. Proteomics, 89:215-26.

M. Altvater, Y. Chang, A. Melnik, L. Occhipinti, S. Schütz, U. Rothenbusch, P. Picotti, V.G. Panse. external pageTargeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear export. (2012) Mol. Syst. Biol., 2012;8:628.

 

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