Prof. Dr. Paola Picotti
Contact
- Location location_onHPM H 46
- Phone phone+41 44 633 25 58
- Fax print+41 44 633 12 98
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Inst. f. Molekulare Systembiologie
Otto-Stern-Weg 3
8093
Zürich
Switzerland
Curriculum vitae
Professional and academic experience
2017- Associate (Tenured) Professor for Molecular Systems Biology, Institute of Molecular Systems Biology, ETH Zurich
2011-17 Assistant Professor for Protein Network Biology, Institute of Biochemistry, ETH Zurich
2007-10 Post-doctoral fellow, Inst. of Molecular Systems Biology, ETH Zurich Supervisor: Prof. Ruedi Aebersold
Education
2006 PhD in Biotechnology, University of Padua, Italy. Supervisor: Prof. Angelo Fontana
2001 Master degree summa cum laude in Pharmaceutical Chemistry and Technologies, University of Padua, Italy
Honours and Awards
2021 HUPO Discovery in proteomics award
2021 Winner of the Life Sciences Falling Walls competition
2021 Guest professorship at the University of Cologne
2020 Rössler Prize, ETH Zürich
2020 Election to the German National Academy of Sciences (Leopoldina)
2019 EMBO Gold Medal
2019 ERC Consolidator Grant
2018 Juan Pablo Albar “Protein Pioneer” Award, European Proteome Organization
2018 Friedrich-Miescher Award
2016 Robert J. Cotter Award, American Human Proteome Organization
2016 SGMS Award for independent research in the field of MS
2016 EMBO Young Investigator Award
2014 ERC Starting Grant
2014 “Top 40 under 40” Power List, The Analytical Scientist
2012 ETH Latsis Prize
2011 Swiss National Foundation Research Professorship
2009 “Tomorrow’s PI”, Genome Technology
2007 Marie Curie Intraeuropean fellowship
Selected Publications
V. Cappelletti, T. Hauser, I. Piazza, M. Pepelnjak, L. Malinovska, T. Fuhrer, Y. Li, C. Dörig, P. Boersema, L. Gillet, J. Grossbach, A. Dugourd, J. Saez-Rodriguez, A. Beyer, N. Zamboni, A. Caflisch, N. de Souza, P. Picotti. external pageDynamic 3D proteomes reveal protein functional alterations at high resolution in situ.call_made (2021) Cell, 184 (2), 545-559. e22.
I. Piazza, N. Beaton, R. Bruderer, T. Knobloch, C. Barbisan, L. Chandat, A. Sudau, I. Siepe, O. Rinner, N. de Souza, P. Picotti, L. Reiter. external pageA machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.call_made (2020) Nat Commun., 11 (1), 1-13.
I. Piazza, K. Kochanowski, V. Cappelletti, T. Fuhrer, E. Noor, U. Sauer, P. Picotti. external pageA Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication.call_made (2018) Cell, Jan 3. pii: S0092-8674(17)31448-4.
S. Schopper, A. Kahraman, P. Leuenberger, Y. Feng, I. Piazza, O. Müller, P.J. Boersema, P. Picotti. external pageMeasuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry.call_made (2017) Nat. Protoc., Nov;12(11):2391-2410.
P. Leuenberger, S. Ganscha, A. Kahraman, V. Cappelletti, P.J. Boersema, C. von Mering, M. Claassen, P. Picotti. external pageCell-wide analysis of protein thermal unfolding reveals determinants of thermostabilitycall_made. (2017) Science, 355 (6327).
M. Soste, R. Hrabakova, S. Wanka, A. Melnik, P. Boersema, A. Maiolica, T. Wernas, M. Tognetti, C. von Mering, P. Picotti. external pageA sentinel protein assay for simultaneously quantifying cellular processescall_made. (2014) Nat Methods,11(10):1045-8.
Y. Feng, G. De Franceschi, A. Kahraman, M. Soste, A. Melnik, P.J. Boersema, P.P. de Laureto, Y. Nikolaev, A.P. Oliveira, P. Picotti. external pageGlobal analysis of protein structural changes in complex proteomescall_made. (2014) Nat. Biotechnol., 32(10):1036-44.
P. Picotti, M. Clément-Ziza, H. Lam, D.S. Campbell, A. Schmidt, E.W. Deutsch, H. Röst, Z. Sun, O. Rinner, L. Reiter, Q. Shen, J.J. Michaelson, A. Frei, S. Alberti, U. Kusebauch, B. Wollscheid, R.L. Moritz, A. Beyer, R. Aebersold. external pageA complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysiscall_made. (2013) Nature, 494(7436):266-70.
P. Picotti, B. Bodenmiller, L.N. Müller, B. Domon, R. Aebersold. external pageFull dynamic range proteome analysis of S. cerevisiae by targeted proteomicscall_made. (2009) Cell, 138(4):795-806.
P. Picotti, O. Rinner, R. Stallmach, F. Dautel, H. Wenschuh, T. Farrah, B. Domon, R. Aebersold. external pageHigh-throughput generation of selected reaction-monitoring assays for proteins and proteomes.call_made (2010) Nat. Methods, 7(1):43-6.
P. Picotti, H. Lam, D. Campbell, E.W. Deutsch, H. Mirzaei, J. Ranish, B. Domon, R. Aebersold. external pageA database of mass spectrometric assays for the yeast proteomecall_made. (2008) Nat. Methods. 5(11):913-4.
M.A. Krzyzaniak, M.T. Zumstein, J.A. Gerez, P. Picotti, A. Helenius. external pageHost cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F proteincall_made. (2013) PLoS Pathog., 9(4):e1003309.
F. Di Girolamo, P.G. Righetti, M. Soste, Y. Feng, P. Picotti. external pageReproducibility of combinatorial peptide ligand libraries for proteome capture evaluated by selected reaction monitoringcall_made. (2013) J. Proteomics, 89:215-26.
M. Altvater, Y. Chang, A. Melnik, L. Occhipinti, S. Schütz, U. Rothenbusch, P. Picotti, V.G. Panse. external pageTargeted proteomics reveals compositional dynamics of 60S pre-ribosomes after nuclear exportcall_made. (2012) Mol. Syst. Biol., 2012;8:628.