Phone: +41 44 633 31 70
Prof. Ruedi Aebersold is one of the pioneers in the field of proteomics. He is known for developing and advancing a series of mass spectrometry based and computational methods that have found wide application in analytical protein chemistry and proteomics. These include novel targeted and quantitative proteomics methods like ICAT reagents, SRM and SWATH-MS and corresponding computational resources including the TransProteomicPipeline, mProphet and openSWATH to analyze and statistically assess the resulting data. In addition, the research interest of Prof. Dr. Aebersold is directed towards methods to analyze modification states of proteins (such as phosphorylation) as well as novel methods to determine the composition, topology and structure of protein complexes. The group has a strong track record to make resources and data publicly accessible.
Prof. Dr. Aebersold and his team of researchers use the protein profiles determined by quantitative proteomics to differentiate cells in different states, such as noncancerous versus cancerous cells, and to systematically study how cells respond to external stimuli. This is expected to lead to new diagnostic markers for disease and to a more complete understanding of the biochemical processes that control and constitute cell physiology on a systems level. To achieve this goal, the researchers develop and use novel quantitative proteomics techniques to measure protein abundance and protein activity across many different samples. In order to gain deeper mechanistic insight into biological processes the focus of the research is increasingly shifting towards determining the cellular organization of the proteome in space and over time.
Prof. Aebersold serves on the Scientific Advisory Committees of numerous academic and private sector research organizations and is a member of several editorial boards in the fields of protein science, genomics, and proteomics. He led SystemsX.ch, the Swiss initiative of systems biology from 2008-2013 and the research of the group has been recognized by numerous prizes and awards.
Prof. Aebersold is a native of Switzerland and obtained his Ph.D. in Cellular Biology at the Biocenter of the University of Basel in 1983. He has held faculty positions at the Universities of Washington and British Columbia until 2000, when he co-founded the Institute for Systems Biology in Seattle. In 2004, he accepted a position as full professor at the Swiss Federal Institute of Technology (ETH) in Zurich, where in January 2005 he founded the Institute of Molecular Systems Biology.
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