Identifying genes involved in growth regulation

Participants

Hugo Stocker, Silvia Gluderer, Christian Werz, Roland Baumgartner, Ingrid Pörnbacher, Ladan Saraf-Zadeh, Julia Lüdke

Genes identified the loss- and gain-of-function screens encode proteins in various signaling pathways including the Insulin signaling pathway and the hippo pathway. The aim of this work is to describe the complex signaling network involved in growth control.

Selected Publications

For a complete list of publications see Pubmed/Hafen E

Support

This work is supported by a grant from the Swiss National Science Foundation, the University of Zurich and ETH Zurich

Gluderer et al. Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth. BMC Dev Biol (2008) vol. 8 (1) pp. 10

Wu et al. The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci USA (2008) vol. 105 (14) pp. 5414-9

Honegger et al. Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol (2008) vol. 7 (3) pp. 10

Nairz et al. Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. Dev Biol (2006) vol. 291 (2) pp. 314-24

Wittwer et al. Susi, a negative regulator of Drosophila PI3-kinase. Dev Cell (2005) vol. 8 (6) pp. 817-27
Reiling et al. Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. Curr Biol (2005) vol. 15 (1) pp. 24-30

Reiling et al. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev (2004) vol. 18 (23) pp. 2879-92

Rintelen et al. The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. Development (2003) vol. 130 (15) pp. 3479-90