Identifying genes involved in growth regulation

Participants

Prashali Bansal, Dr. Hugo Stocker

Project Overview

Genes identified in the loss- and gain-of-function screens encode proteins in various signaling pathways including the Insulin signaling pathway and the Hippo pathway. The aim of this work is to describe the complex signaling network involved in growth control.

Selected Publications

For a complete list of publications see Pubmed/Hafen E

Baumgartner R, Poernbacher I, Buser N, Hafen E, Stocker H. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell. 2010 Feb 16;18(2):309-16.

Gluderer S, Brunner E, Germann M, Jovaisaite V, Li C, Rentsch CA, Hafen E, Stocker H. Madm (Mlf1 adapter molecule) cooperates with Bunched A to promote growth in Drosophila. J Biol. 2010;9(1):9. Epub 2010 Feb 11.

Werz C, Köhler K, Hafen E, Stocker H. The Drosophila SH2B family adaptor Lnk acts in parallel to chico in the insulin signaling pathway. PLoS Genet. 2009 Aug;5(8):e1000596. Epub 2009 Aug 14.

Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol. 2001 Feb 20;11(4):213-21.

Böhni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, Andruss BF, Beckingham K, Hafen E. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell. 1999 Jun 25;97(7):865-75.

Support

This work is supported by a grant from the Swiss National Science Foundation, the University of Zurich and ETH Zurich