Dr. Duncan Holbrook-Smith
Professur für Systembiologie
HPT D 59
Auguste-Piccard-Hof 18093 Zürich
Receptors are important proteins that control diverse cellular processes. Despite extensive study, the biological roles and mechanisms of action of many receptors remain poorly understood. Chemical probes are small molecules that can be used to perturb the activity of target macromolecules and can be applied to understand these proteins. I am interested in using chemical probes, and chemical genomic approaches more broadly, to understand mechanisms of receptor function.
I joined the Sauer lab in October of 2016 with the goals of mobilizing non-targeted metabolomics as a tool to enable parallelized discovery of chemical probes for receptor-like proteins in yeast, and using those chemical probes to better understand the specific roles of receptor-like proteins in that system. Before joining the Sauer lab I obtained my PhD under the supervision of Dr. Peter McCourt at the University of Toronto. My PhD work focused on the discovery and utilization of chemical probes with the goal of understanding mechanisms of signal transduction by hormone receptors in A. thaliana and S. hermonthica.