Juan Atilio Gerez
Juan completed his undergraduate studies in biology at Buenos Aires University, Argentina. He did his PhD at the same university (2005-2010) and in his thesis, Juan characterized a recently identified protein involved in the SUMOylation and hypoxia signaling pathways. Juan came to the Picotti lab to learn how to apply systems biology concepts, such as discovery and targeted proteomics, to characterize cellular responses to protein misfolding, either in physiological or pathological contexts. He is using dopaminergic neuronal cells as a model system for protein aggregation-dependent cytotoxicity characteristics of several human neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. Juan is a postdoctoral fellow of the European Molecular Biology Organization (EMBO).
Publications
M.A. Krzyzaniak, M.T. Zumstein, J.A. Gerez, P. Picotti, A. Helenius. external pageHost cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the f protein. (2013) PLoS Pathog., Apr (4):e1003309.
J. Druker, A.C. Liberman, M. Antunica-Noguerol, J. Gerez, M. Paez-Pereda, T. Rein, J.A. Iñiguez-Lluhí, F. Holsboer, E. Arzt. external pageRSUME enhances Glucocorticoid Receptor SUMOylation and transcriptional activity. (2013) Mol Cell Biol., 33(11):2116-27
J. Gerez, M. Fuertes, L. Tedesco, S. Silberstein, G. Sevlever, M. Paez-Pereda, F. Holsboer, A.G. Turjanski, E. Arzt. external pageIn Silico Structural and Functional Characterization of the RSUME Splice Variants. (2013) PLoS One, 2013;8(2).
B. Shan, J. Gerez, M. Haedo, M. Fuertes, M. Theodoropoulou, M. Buchfelder, M. Losa, G.K. Stalla, E. Arzt, U. Renner. external pageRSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells. (2012) Endocr Relat Cancer, 19(1):13-27
F. Pelisch, J. Gerez, J. Druker, I.E. Schor, M.J. Muñoz, G. Risso, E. Petrillo, B.J. Westman, A.I. Lamond, E. Arzt, A. Srebrow. external pageThe serine/arginine-rich protein SF2/ASF regulates protein sumoylation. (2010) Proc Natl Acad Sci. U S A, 107(37):16119-24.
M. Fuertes, J. Gerez, M. Haedo, D. Giacomini, M. Páez-Pereda, M. Labeur, G.K. Stalla, E. Arzt. external pageCytokines and genes in pituitary tumorigenesis: RSUME role in cell biology. (2010) Front Horm Res., 38:1-6.
D. Giacomini, M. Haedo, J. Gerez, J. Druker, M. Páez-Pereda, M. Labeur, G.K. Stalla, E. Arzt. external pageDifferential gene expression in models of pituitary prolactin-producing tumoral cells. (2009) Horm Res., 71 Suppl 2:88-94.
U. Renner, E.C. De Santana, J. Gerez, B. Fröhlich, M. Haedo, M.P. Pereda, C. Onofri, G.K. Stalla, E. Arzt. external pageIntrapituitary expression and regulation of the gp130 cytokine interleukin-6 and its implication in pituitary physiology and pathophysiology. (2009) Ann N Y Acad Sci.,1153:89-97.
M.R. Haedo, J. Gerez, M. Fuertes, D. Giacomini, M. Páez-Pereda, M. Labeur, U. Renner, G.K. Stalla, E. Arzt. external pageRegulation of pituitary function by cytokines. (2009) Horm Res., 72(5):266-74.
A. Carbia-Nagashima*, J. Gerez*, C. Perez-Castro, M. Paez-Pereda, S. Silberstein, G.K. Stalla, F. Holsboer, E. Arzt. external pageRSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. (2007) Cell, 131(2):309-23. (*Equally contributed)
J. Gerez, J. Bonfiglio, S. Sosa, D. Giacomini, M. Acuña, A.C. Nagashima, M.J. Perone, S. Silberstein, U. Renner, G.K. Stalla, E. Arzt. external pageMolecular transduction mechanisms of cytokine-hormone interactions: role of gp130 cytokines. (2007) Exp Physiol., 92(5):801-6.
D. Giacomini, M. Acuña, J. Gerez, A.C. Nagashima, S. Silberstein, M. Páez-Pereda, M. Labeur, M. Theodoropoulou, U. Renner, G.K. Stalla, E. Arzt. external pagePituitary action of cytokines: focus on BMP-4 and gp130 family. (2007) Neuroendocrinology. 85(2):94-100.
D. Giacomini, M. Páez-Pereda, M. Theodoropoulou, J. Gerez, A.C. Nagashima, A. Chervin, S. Berner, M. Labeur, D. Refojo, U. Renner, G.K. Stalla, E. Arzt. external pageBone morphogenetic protein-4 control of pituitary pathophysiology. (2006) Front Horm Res., 35:22-31.
D. Giacomini, M. Páez-Pereda, M. Theodoropoulou, M. Labeur, D. Refojo, J. Gerez, A. Chervin, S. Berner, M. Losa, M. Buchfelder, U. Renner, G.K. Stalla, E. Arzt. external pageBone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action. (2006) Endocrinology, 147(1):247-56.