The role of insulin signaling and autophagy in oogenesis

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Izzet Mehmet Akcay
Izzet Mehmet Akcay
Katja Koehler
Dr. Katja Koehler

Project Overview

Oogenesis in Drosophila is a highly energy demanding process and thus under strict nutrient dependent regulation. Starvation and reduced insulin signaling block oocyte maturation. The goal of this project is to understand the role of autophagy in insulin dependent regulation of oogenesis.


Selected Publications

Barth JM , Szabad J, Hafen E, Köhler KAutophagy in Drosophila ovaries is induced by starvation and is required for oogenesisCell Death Differ. 2011 Jun;18(6):915-24. Epub 2010 Dec 10.

Köhler K , Brunner E, Guan XL, Boucke K, Greber UF, Mohanty S, Barth JM , Wenk MR, Hafen E. A combined proteomic and genetic analysis identifies a role for the lipid desaturase Desat1 in starvation-induced autophagy in DrosophilaAutophagy. 2009 Oct;5(7):980-90. Epub 2009 Oct 22.

Honegger B, Galic M, Köhler K, Wittwer F, Brogiolo W, Hafen E, Stocker H. Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistanceJ Biol (2008) vol. 7 (3) pp. 10

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