Systems Genetics of Starvation Responses

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Participants

Izzet Mehmet Akcay
Izzet Mehmet Akcay
Katja Koehler
Dr. Katja Koehler

Project Overview

To dissect the genetic basis of starvation responses, we take a systems genetics approach using a set of inbred Drosophila lines (the Drosophila Genetic Reference Panel, DGRP). Differences in starvation sensitivities at larval stages will be associated with molecular polymorphisms to identify genetic loci responsible for the variation in this trait. We are especially interested in variations related to autophagy and TOR signaling as executors of starvation responses.

Relevant Literature

Mackay TF, Richards S, Stone EA, Barbadilla A, Ayroles JF, Zhu D, Casillas S, Han Y, Magwire MM, Cridland JM, Richardson MF, Anholt RR, Barrón M, Bess C, Blankenburg KP, Carbone MA, Castellano D, Chaboub L, Duncan L, Harris Z, Javaid M, Jayaseelan JC, Jhangiani SN, Jordan KW, Lara F, Lawrence F, Lee SL, Librado P, Linheiro RS, Lyman RF, Mackey AJ, Munidasa M, Muzny DM, Nazareth L, Newsham I, Perales L, Pu LL, Qu C, Ràmia M, Reid JG, Rollmann SM, Rozas J, Saada N, Turlapati L, Worley KC, Wu YQ, Yamamoto A, Zhu Y, Bergman CM, Thornton KR, Mittelman D, Gibbs RA. The Drosophila melanogaster Genetic Reference PanelNature. 2012 Feb 8;482(7384):173-8. doi: 10.1038/nature10811.

Mackay TF. Philos Trans R Soc Lond B Mutations and quantitative genetic variation: lessons from DrosophilaBiol Sci. 2010 Apr 27. Review

Ayroles JF, Carbone MA, Stone EA, Jordan KW, Lyman RF, Magwire MM, Rollmann SM, Duncan LH, Lawrence F, Anholt RR, Mackay TF.System genetics of complex traits in Drosophila melanogasterNat Genet. 2009 Mar

 
 
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