Population genetics of growth

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Dr. Sibylle Vonesch
Dr. Sibylle Vonesch

Project Overview

To understand and characterize the networks underlying polygenic traits, like organ size and shape, a more systemic approach than the classical genetics approach is needed. We work with a panel of inbred  Drosophila  lines, using approaches from population and systems genetics to identify genotype-phenotype associations for wing and body size traits and construct biologically meaningful interaction networks.

Relevant Literature

Mackay TF. Philos Trans R Soc Lond B Mutations and quantitative genetic variation: lessons from DrosophilaBiol Sci. 2010 Apr 27. Review

Jumbo-Lucioni P, Ayroles JF, Chambers MM, Jordan KW, Leips J, Mackay TF, De Luca M. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogasterBMC Genomics. 2010 May

Mackay TF, Stone EA, Ayroles JF. The genetics of quantitative traits: challenges and prospectsNat Rev Genet. 2009 Aug

Ayroles JF, Carbone MA, Stone EA, Jordan KW, Lyman RF, Magwire MM, Rollmann SM, Duncan LH, Lawrence F, Anholt RR, Mackay TF. Genetics of complex traits in Drosophila melanogasterNat Genet. 2009 Mar

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