Population genetics of growth
To understand and characterize the networks underlying polygenic traits, like organ size and shape, a more systemic approach than the classical genetics approach is needed. We work with a panel of inbred Drosophila lines, using approaches from population and systems genetics to identify genotype-phenotype associations for wing and body size traits and construct biologically meaningful interaction networks.
Mackay TF. Philos Trans R Soc Lond B Mutations and quantitative genetic variation: lessons from Drosophila. Biol Sci. 2010 Apr 27. Review
Jumbo-Lucioni P, Ayroles JF, Chambers MM, Jordan KW, Leips J, Mackay TF, De Luca M. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. BMC Genomics. 2010 May
Mackay TF, Stone EA, Ayroles JF. The genetics of quantitative traits: challenges and prospects. Nat Rev Genet. 2009 Aug
Ayroles JF, Carbone MA, Stone EA, Jordan KW, Lyman RF, Magwire MM, Rollmann SM, Duncan LH, Lawrence F, Anholt RR, Mackay TF. Genetics of complex traits in Drosophila melanogaster. Nat Genet. 2009 Mar