Dr. Hirokazu Okada
Hirokazu Okada received his bachelor's and master's degrees in Physics from Tokyo University of Science. He received his Ph.D. from Columbia University for his work on the proteomic analysis of BACE1 regulatory mechanisms in Alzheimer's disease. He then joined Scott Soderling's lab at Duke University and developed proteomics tools featuring photo-activatable amino acid cross-linkers to photo-trap protein interactions in vivo and in vitro. He joined Ernst Hafen's lab in 2012 and works on proteomics-centered systems genetics on Drosophila wing growth. In collaboration with Aebersold Group, he performed a proteome-wide association study (PWAS) on a wing-size phenotype.
- Okada H, Ebhardt HA, Vonesch SC, Aebersold R, Hafen E. (2016) Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Nature Commun. 7:12649.
- Okada H*, Schittenhelm RB*, Straessle A, Hafen E. (2015) Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex. PLoS One. 10(3):e0113902.
* co-first authors
- Uezu A, Okada H, Murakoshi H, del Vescovo CD, Yasuda R, Diviani D, Soderling SH. Modified SH2 domain to phototrap and identify phosphotyrosine proteins from subcellular sites within cells. (2012) Proc Natl Acad Sci U S A. 109(43):E2929-38.
- Okada H, Uezu A, Soderblom EJ, Moseley MA 3rd, Gertler FB, Soderling SH. Peptide array X-linking (PAX): a new peptide-protein identification approach. (2012) PLoS One. 7(5):e37035.
- Okada H, Uezu A, Mason FM, Soderblom EJ, Moseley MA 3rd, Soderling SH. (2011) SH3 domain-based phototrapping in living cells reveals Rho family GAP signaling complexes. Science Signal. 4(201):rs13.
- Finan GM, Okada H, Kim TW. BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin. (2011) J Biol Chem. 286(14):12602-16.
- Okada H, Zhang W, Peterhoff C, Hwang JC, Nixon RA, Ryu SH, Kim TW. Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing. (2010) FASEB J. 24(8):2783-94.
- Okada H, Soderling SH. (2009) Signaling through actin to regulate spine formation and function. Open Neurosci J. 2009;3:97-107.
- Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, Honig L, Vonsattel JP, Kim TW. (2005) Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol. 58(6):909-19.