Postdoctoral position: functional proteomics of immune checkpoint signaling
We are looking for a candidate who is highly motivated to study the mechanisms through which tumor cells impede T cell functions. Specifically the candidate will study signalosome dynamics in primary effector T cells under physiological conditions using mass spectrometry based proteomics and phosphoproteomics techniques to develop an integrated model on the mechanisms of action of PD-1 and other key T cell co-inhibitors in cancer. Such models will provide a rationale for the design of new immunotherapeutic agents. The projects builds on a previous collaboration (Roncagalli R. et al., Nat Immunol. 2014) with the lab of Bernard Malissen (Centre d’Immunophénomique, Marseille-Luminy, France) and uniquely combines state of the art mouse genetics with quantitative proteomics to analyze signaling processes at physiological conditions.
The candidate should hold a PhD in biochemistry and be familiar with mass spectrometric analysis of proteins. Experience in developing computational methods for MS data analysis and interpretation is a plus. The successful candidate should be a team player with excellent communication skills and actively engage in research. The position is immediately available and will be situated at the Institute of Molecular Systems Biology on the ETH Hönggerberg Campus.
For further information please contact Dr. Matthias Gstaiger (no applications) by E-Mail and visit our website.
Applications with a full CV, list of publications, short statement of experience and qualification (one page) should be submitted online (button “Apply now” below) to: ETH Zurich, Michael Wobmann, Human Resources, 8092 Zurich.