Dr. Patrick Pedrioli
Patrick Pedrioli was born in the southern part of Switzerland called Ticino. In 1996 he began his biochemistry studies at the Eidgenössische Technische Hochschule (Swiss Federal Institute for Technology) in Zurich (ETHZ). During this period his research interests focused on the directed evolution of novel protein functions, and on the construction and use of phage display libraries of small proteins. After obtaining a degree in natural sciences, in 2001 he moved to Seattle to join the group of Ruedi Aebersold in the newly founded Institute for Systems Biology. There, working as an external PhD student of the ETHZ, his research focused on the development of biochemical and in silico methodologies for proteomics research. In Seattle he developed an interest in post-translational protein modifications, such as the ubiquitin-like modifiers (UBLs), and the role they play in regulating the properties of biological systems. After obtaining a PhD in Natural Sciences in 2005, Patrick joined the group of Matthias Peter in the Institute for Biochemistry at the ETHZ as a postdoctoral fellow. There he unraveled an unexpected function for the Ubiquitin Related Modifier Urm1 in the post-transcriptional modification of uridine residues at the wobble positions of tRNA molecules.