Dr. Evan Williams

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Evan G. Williams

ETH Zurich

Inst. f. Molekulare Systembiologie

Dr. Evan Graehl Williams

HPT E 55

Auguste-Piccard-Hof 1

8093 Zürich


  • vcard V-Card (vcf, 1kb)

Evan Williams obtained his bachelor's degree in Bioengineering at Rice University in 2009 and his doctorate in Bioengineering at the École Polytechnique Fédérale de Lausanne (EPFL)  in 2015. At the EPFL, Evan worked in the laboratory of Johan Auwerx on the population genetics of metabolism and gene–environment interactions in the BXD reference population. This research identified several novel gene–phenotype links, both for complex metabolic diseases such as type II diabetes and for rare semi-Mendelian metabolic diseases. Since 2016, Evan has worked in the group of Ruedi Aebersold at the Eidgenössische Technische Hochschule Zürich (ETHZ) on the implementation of SWATH proteomics in genetically-variable populations, and the subsequent trans-omic integration of these systems proteomics datasets with genome, transcriptome, metabolome, and phenome data. 


As First Author:

  • Williams EG* and Wu Y*, Jha P, Dubuis S, Blattmann P, Argmann CA, Houten SM, Amariuta T, Wolski W, Zamboni N, Aebersold R and Auwerx J. "Systems preotomics of liver mitochondria function." Science, 2016. *co-first authors
  • Williams EG, Auwerx J. "The convergence of systems and reductionist approaches in complex trait analysis." Cell, 2015. 
  • Williams EG, Mouchiroud L, Frochaux M, Pandey A, Andreux PA, Deplancke B, Auwerx J. "An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement." PLoS Genetics, 2014.
  • Wu Y*, Williams EG*, Dubuis S, Mottis A, Jovaisaite V, Houten SM, Argmann CA, Faridi P, Wolski W, Kutalik Z, Zamboni N, Auwerx J, Aebersold R. "Multilayered genetic and omics dissection of mitochondrial activity in a mouse reference population." Cell, 2014. *co-first authors
  • Andreux PA*, Williams EG*, Koutnikova H, Houtkooper RH, Champy MF, Henry H, Schoonjans K, Williams RW, Auwerx J. "Systems genetics of metabolism - the use of the BXD murine reference panel for multiscalar integration of traits." Cell, 2012. *co-first authors

As Contributing Author:

  • Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J. "Urolithin A improves lifespan in C. elegans and muscle function in rodents by inducing mitophagy." Nature Medicine, 2016.
  • Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, JordanD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Uhlein SN, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A. "Two conserved histone demethylases regulate mitochondrial stress-induced longevity." Cell, 2016. 
  • Wang X, Pandey AK, Mulligan MK, Williams EG, Mozhui K, Li Z, Jovaisaite V, Quarles LD, Xiao Z, Huang J, Capra JA, Chen Z, Taylor WL, Bastarache L, Niu X, Pollard KS, Ciobanu DC, Reznik AO, Tishkov AV, Zhulin IB, Peng J, Nelson SF, Denny JC, Auwerx J, Lu L, Williams RW. "Joint mouse–human phenome-wide association to test gene function and disease risk." Nature Communications, 2016.
  • Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J. "Tetracyclines disturb mitochondrial function across eukaryotic models: a call for caution in biomedical research." Cell Reports, 2015.
  • Van der Weijer T, Phielix E, Bilet L, Williams EG, Laufs A, Livingstone R, Nowotny P, Sparks LM, Paglialunga S, Szendroedi J, Havekes B, Moullan N, Pirinen E, Hwang JH, Schrauwen-Hinderling VB, Hesselink MKC, Auwerx J, Roden M, Schrauwen P. "Evidence for a direct effect of the NAD+ precursor Acipimox on mitochondrial function in humans." Diabetes, 2014.
  • Pirinen E, Canto C, Jo YS, Morato L, Zhang H, Menzies K, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve A, Schoonjans K, Auwerx J. "Pharmacological inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle." Cell Metabolism, 2014.
  • Hasenfuss SC, Bakiri L, Thomsen MK, Williams EG, Auwerx J, Wagner EF. "Regulation of steatohepatitis and PPARg signaling by distinct AP-1 dimers." Cell Metabolism, 2014.
  • McKnite AM, Perez-Munoz ME, Lu L, Williams EG, Brewer S, Andreux P, Bastiaansen J, Wang X, Kachman S, Auwerx J, Williams RW, Benson A, Peterson D, Ciobanu D. "Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits." PLoS One, 2012.
  • Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J. "NCoR1 is a conserved physiological modulator of muscle mass and oxidative function." Cell, 2011.
Page URL: http://www.imsb.ethz.ch/research/aebersold/people/EvanWillams.html
Mon Jun 26 19:00:40 CEST 2017
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