Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals
Histone modification profiling in rare stem cell populations: our collaborative work on the epigenetics in muscle stem cell aging got published in Nature!
The functionality of stem cells declines during ageing. Here we show that an epigenetic stress response in muscle stem cells differs between aged and young mice. By generating time-resolved signatures of histone modifications, we predicted chromatin modifiers that partially restore reduced proliferation of aged stem cells. Aberrant chromatin activation leads to increased expression of HoxA9, which in turn activates early embryonic developmental pathways. Inhibition of aberrant chromatin activation or deletion of Hoxa9 improves stem cell function and muscle regeneration in aged mice.
Schwoerer S, Becker F, Feller C, Baig AH, Koeber U, Henze H, Kraus JM, Xin B, Lechel A, Lipka DB, Varghese CS, Schmidt M, Rohs R, Aebersold R, Medina KL, Kestler HA, Neri F, von Maltzahn J*, Tuempel S*, Rudolph KL*. Epigenetic stress responses induce muscle stem cell aging by Hoxa9 developmental signals. Nature 2016 (in press). Doi: 10.1038/nature20603. *Co-corresponding authors.
Histone profiling in stem cells (2 min interview by Simon Schwörer): https://share.fli-leibniz.de/index.php/s/u7cSM60LW86yxYZ
Link to Press release from FLI Jena:
Video interviews with authors: