Student Projects

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As a an active research unit, we continuously offer a variety of wet and dry bench projects for Master students lasting 3 or 6 months. Some examples are listed below. As this list gets rapidly outdated, don't hesitate in contacting directly the Principal Investigator of interest.


Hafen Lab: Master thesis/semester project on CRISPR/Cas9-mediated SNP changes to elucidate cause of size variations

How genetic variation (e.g. SNP) leads to different traits/phenotypes in natural populations is a fundamental and challenging problem in both the life and medical sciences. This project will involve several objectives to tackle this problem by first establishing an efficient in vivo CRISPR/Cas9 method and then using this method to change phenotype-associated SNPs in inbred Drosophila lines derived from a natural population. Read more 


Aebersold lab: Master thesis/semester project in quantitative AP-MS of signalling complexes

TNF-alpha is a cytokine playing a central role in inflammation that induces the formation of a large signaling complex associated with its receptor. The project will primarily entail the application of quantitative mass spectrometry methods to obtain detailed information about this large assembly. The student will learn protein purification, experimental and computational aspects of AP-MS, and is expected to know basics of mass spectrometry and cell culture. Read more 


Aebersold lab: student project focused on method development in chemical cross-linking/mass spectrometry

Most proteins execute the in the form of protein complexes. Chemical cross-linking coupled to mass spectrometry is a strategy to learn about the spatial organization of protein complexes. Our group is one of the world-wide leaders in this field. We are continuously optimizing our workflows and are looking for students to support us in this endeavor. The student will learn how to perform cross-linking experiments and perform the data analysis. For further information, contact Dr. Michael Ewing Read more 


Aebersold lab: Master thesis/semester project in interactomic studies of signaling complexes

The most widely utilized mass spec(MS)-based method to determine protein-protein interaction is based on affinity purification (AP-MS). Recently, a suite of methods have been developed to determine the proximal proteome of a target protein by biotin labeling, providing information complementary to AP-MS. In this project, the student will apply a combination of AP-MS and proximity labeling to exhaustively define the full and dynamic interactome of key players in innate immunity.  Read more 


Aebersold lab: Semester project in identification of plant membrane protein-protein interaction

All plant cells are encapsulated by a cellulose-rich cell wall, which performs a range of functions in plant growth and development. Despite extensive research, little is known about the biosynthesis of the cellulose. This project aims to explore methods of detection of the cellulose synthase complex within the Golgi apparatus of Arabidopsis. The student will work on detergent selection for complex solubilization, after which he/she will perform AP-MS and subsequent data analysis. Read more 


Semester project (Sauer group): Discovery of novel kinases in E. coli that regulate enzyme activity

Research project available on the discovery of novel kinases in E. coli that are crucial for enzyme activity regulation in metabolism. Read more 


Sauer group: Interplay of posttranslational modification sites in enzyme activity regulation (Master project)

Research project available on investigating the interplay and protein activity fine-tuning of different posttranslational modifications (PTM) sites Read more 


Sauer group: Metabolomics and Flux Balance Analysis in Saccharomyces cerevisiae (Semester/Master Project)

Research project available on investigating the regulation of metabolism in S. cerevisiae, via enzyme phosphorylation Read more 


Aebersold lab: Master Thesis in Population Genetics—Analyzing Proteomics in a Diverse Population to Uncover Mechanisms of Aging

The process of aging can be better understood from a systems biology approach—examining how entire cellular pathways change across time. This project involves generating then analyzing transcriptomic, proteomic, and metabolomic data from liver tissue of 660 individual mice from different ages, which also segregate by genetics and diet. Project keywords: genetics, aging, multi-omics, metabolism, bioinformatics, statistics, systems biology, big data, personalized medicine. Read more 


Zamboni group, Metabolomics & network analysis

Research project available on investigating metabolic response to mitochndrial defects in yeast Read more 

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