Student Projects

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As a an active research unit, we continuously offer a variety of wet and dry bench projects for Master students lasting 3 or 6 months. Some examples are listed below. As this list gets rapidly outdated, don't hesitate in contacting directly the Principal Investigator of interest.


Aebersold lab: Master thesis/semester project in interactomic studies of signaling complexes

The most widely utilized mass spec(MS)-based method to determine protein-protein interaction is based on affinity purification (AP-MS). Recently, a suite of methods have been developed to determine the proximal proteome of a target protein by biotin labeling, providing information complementary to AP-MS. In this project, the student will apply a combination of AP-MS and proximity labeling to exhaustively define the full and dynamic interactome of key players in innate immunity.  Read more 


Aebersold lab: Semester project in identification of plant membrane protein-protein interaction

All plant cells are encapsulated by a cellulose-rich cell wall, which performs a range of functions in plant growth and development. Despite extensive research, little is known about the biosynthesis of the cellulose. This project aims to explore methods of detection of the cellulose synthase complex within the Golgi apparatus of Arabidopsis. The student will work on detergent selection for complex solubilization, after which he/she will perform AP-MS and subsequent data analysis. Read more 


Hafen Group Master Thesis Project: CRISPR/Cas9-mediated SNP changes to elucidate cause of size variations

The project consists of three objectives: (1) evaluation of the PWAS candidates by transgenic RNAi, (2) establishment of efficient fly CRISPR/Cas9 method(s) for SNP changes, and (3) SNP changes in inbred natural population lines. We have already achieved significant progress on the first two objectives. Therefore, student(s) will be able to obtain results using newly generated reagents/systems soon after initiating the project.  Read more 


Semester project (Sauer group): Discovery of novel kinases in E. coli that regulate enzyme activity

Research project available on the discovery of novel kinases in E. coli that are crucial for enzyme activity regulation in metabolism. Read more 


Sauer group: Interplay of posttranslational modification sites in enzyme activity regulation (Master project)

Research project available on investigating the interplay and protein activity fine-tuning of different posttranslational modifications (PTM) sites Read more 


Sauer group: Metabolomics and Flux Balance Analysis in Saccharomyces cerevisiae (Semester/Master Project)

Research project available on investigating the regulation of metabolism in S. cerevisiae, via enzyme phosphorylation Read more 


Aebersold lab: Master thesis/semester project in quantitative AP-MS of signaling complexes

TNF-alpha is a cytokine playing a fundamental role in inflammation that induces the formation of a large signaling complex associated with its receptor. The project will entail optimization of AP-MS workflow applied to this complex. The student will learn protein purification, experimental and computational aspects of AP-MS and possibly other proteomics techniques. The student is expected to know basics of mass spectrometry and cell culture and have a strong interest in method development. Read more 


Aebersold lab: Master Thesis in Population Genetics—Analyzing Proteomics in a Diverse Population to Uncover Mechanisms of Aging

The process of aging can be better understood from a systems biology approach—examining how entire cellular pathways change across time. This project involves generating then analyzing transcriptomic, proteomic, and metabolomic data from liver tissue of 660 individual mice from different ages, which also segregate by genetics and diet. Project keywords: genetics, aging, multi-omics, metabolism, bioinformatics, statistics, systems biology, big data, personalized medicine. Read more 


Zamboni group, Metabolomics & network analysis

Research project available on investigating metabolic response to mitochndrial defects in yeast Read more 


Aebersold group: Master Thesis of systems biology to reveal the protein turnover behaviors in human cancer cells

The student will learn how to efficiently process samples for mass spectrometry analysis at a large scale, how to perform and maintain a mass spectrometer for their own samples in SWATH-MS mode, and how to analyze the data generated using systems biology perspectives. Read more 

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Mon May 01 08:11:15 CEST 2017
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